As soon as it touches THP, the voltage-gated Na-channel opens and lots of Na comes in and progressively neutralizes the electronegativity.
THP will become -60mV then -50mV, -40mV, and eventually becomes 0mV. This membrane potential is progressively going to positive value e.g.: +10mV. Now we can say that membrane lost its negative polarity and depolarized.Īfter depolarization of the cell, depolarization sensitive channels. i.e., Ca and K-channels, both are activated.
K starts rushes outside because intracellular K is normally more as compared to extracellular K.
